Abnormal expression of TFⅢB subunits and RNA Pol Ⅲ genes is associated with hepatocellular carcinoma
10.1016/j.livres.2017.08.005
- Author:
Lei JUNXIA
1
;
Chen SONGLIN
;
Zhong SHUPING
Author Information
1. School of Medicine
- Keywords:
RNA polymerase Ⅲ(Pol Ⅲ);
TFIIB-related factor 1(Brf1);
Hepatocellular carcinoma(HCC);
c-Jun amino-terminal kinase(JNKs);
Histone H3
- From:
Liver Research
2017;1(2):112-120
- CountryChina
- Language:Chinese
-
Abstract:
The levels of the products of RNA polymerase Ⅲ-dependent genes(Pol Ⅲ genes),including tRNAs and 5S rRNA,are elevated in transformed and tumor cells,which potentiate tumorigenesis.TFIIB-related factor 1(Brf1)is a key transcription factor and specifically regulates the transcription of Pol Ⅲ genes.In vivo and in vitro studies have demonstrated that a decrease in Brf1 reduces Pol Ⅲ gene transcription and is suf-ficient for inhibiting cell transformation and tumor formation.Emerging evidence indicates that dys-regulation of Brf1 and Pol Ⅲ genes is linked to the development of hepatocellular carcinoma(HCC)in humans and animals.We have reported that Brf1 is overexpressed in human liver cancer patients and that those with high Brf1 levels have shorter survivals.This review summarizes the effects of dysregu-lation of these genes on HCC and their regulation by signaling pathways and epigenetics.These novel data should help us determine the molecular mechanisms of HCC from a different perspective and guide the development of therapeutic approaches for HCC patients.
