Diagnostic and therapeutic potentials of microRNAs in cholangiopathies
10.1016/j.livres.2017.03.003
- Author:
Kennedy LINDSEY
1
;
Francis HEATHER
;
Meng FANYIN
;
Glaser SHANNON
;
Alpini GIANFRANCO
Author Information
1. Research
- Keywords:
microRNAs;
Cholangiopathies;
Diagnosis;
Therapy
- From:
Liver Research
2017;1(1):34-41
- CountryChina
- Language:Chinese
-
Abstract:
Cholangiopathies are a group of rare,devastating diseases that arise from damaged cholangiocytes,the cells that line the intra-and extra-hepatic bile ducts of the biliary epithelium.Cholangiopathies result in significant morbidity and mortality and are a major cause of liver transplantation.A better understanding of the underlying pathogenesis that influences cholangiocyte dysregulation and cholangiopathy pro-gression is necessary,considering the dismal prognosis associated with these diseases. MicroRNAs are a class of small,non-coding RNAs that regulate post-transcriptional mRNA expression of specific genes.The role of microRNAs has expanded to include the initiation and development of many diseases,including cholangiopathies.Understanding microRNA regulation of cholangiopathies may provide diagnostic and therapeutic benefit for these diseases.In this review,the authors primarily focus on studies published within the last five years that help determine the diagnostic and therapeutic po-tential of microRNAs in cholangiopathies.
