Bile acid metabolism and signaling in liver disease and therapy
10.1016/j.livres.2017.05.001
- Author:
Y.L.Chiang JOHN
1
Author Information
1. Department of Integrative Medical Sciences
- Keywords:
Bile acid metabolism;
Cholestatic liver diseases;
Metabolic diseases
- From:
Liver Research
2017;1(1):3-9
- CountryChina
- Language:Chinese
-
Abstract:
Bile acids play a critical role in the regulation of glucose,lipid,and energy metabolism through activation of the nuclear bile acid receptor farnesoid X receptor(FXR)and membrane G protein-coupled bile acid receptor-1(Gpbar-1,aka TGR5).Agonist activation of FXR and TGR5 improves insulin and glucose sensitivity and stimulates energy metabolism to prevent diabetes,obesity,and non-alcoholic fatty liver disease(NAFLD).Bile acids have both pro-and anti-inflammatory actions through FXR and TGR5 in the intestine and liver.In the intestine,bile acids activate FXR and TGR5 to stimulate fibroblast growth factor 15 and glucagon-like peptide-1 secretion.FXR and TGR5 agonists may have therapeutic potential for treating liver-related metabolic diseases,such as diabetes and NAFLD.
