Discussion on the effect of epithelial-interstitial transformation on idiopathic pulmonary fibrosis based on "deficient-qi induced stagnation"
10.3760/cma.j.cn115398-20231127-00310
- VernacularTitle:基于“虚气留滞”探讨上皮间质转化对特发性肺纤维化的影响
- Author:
Yuanhang YE
1
;
Cheng LUO
;
Bo NING
;
Jing KAN
Author Information
1. 湖北中医药大学中医学院，武汉 430060
- Keywords:
Pulmonary disease, idiopathic;
Epithelial to mesenchymal transition;
Deficient-qi induced stagnation;
Basic theory of Traditional Chinese Medicine
- From:
International Journal of Traditional Chinese Medicine
2024;46(12):1543-1548
- CountryChina
- Language:Chinese
-
Abstract:
Idiopathic pulmonary fibrosis (IPF) is a terminal disease of the lung. Its pathogenesis mechanism and pathogenesis evolution are very complex, which is closely related to epithelial-mesenchymal transformation (EMT). Under the guidance of the theory of "deficient-qi induced stagnation", this article elaborated on the relationship between IPF, "deficient-qi induced stagnation", and EMT from the perspective of TCM and Western medicine. It is believed that "deficient-qi induced stagnation" is the macroscopic pathogenesis of IPF, and EMT is the microscopic mechanism of IPF. The micro-mechanism was to inhibit EMT as the treatment target to prevent epithelial cell injury and apoptosis, thus reducing the release of inflammatory factors, pro-fibrosis factors and other factors that damage lung tissue and the transformation of damaged epithelial cells into fibroblasts and produce a large number of ECM deposition; the occurrence and development process of IPF was summarized in the macro pathogenesis. It was highly condensed that IPF was based on "deficiency-qi", "stagnation" as the standard, and the basic pathogenesis characteristics of "stagnation" due to deficiency, as well as the pathogenesis development characteristics of the vicious cycle of "deficiency leads to stagnation, and from stagnation to deficiency". Based on the theory of "deficient-qi induced stagnation", it should be used to tonify deficiency and clear stagnation; tonifying deficiency includes replenishing lung qi, benefiting qi and nourishing yin, and mutual generation between metal and water; clearing stagnation includes circulating qi and blood, drying the wetness and eliminating phlegm, and promoting blood circulation for removing obstruction in collaterals, etc. In clinical application, attention should be paid to the fact that tonifying deficiency and clearing stagnation should be used in parallel.
