Study on medication law of Piao Bingkui for the treatment of lung cancer based on data mining
10.3760/cma.j.cn115398-20240423-00266
- VernacularTitle:基于数据挖掘的朴炳奎治疗肺癌用药规律研究
- Author:
Hui WANG
1
;
Yaxin YE
;
Bingkui PIAO
Author Information
1. 中国中医科学院广安门医院肿瘤科，北京 100053
- Keywords:
Lung neoplasm;
Piao Bingkui;
Data mining;
Medication rules;
Ancient and modern medical record cloud platform
- From:
International Journal of Traditional Chinese Medicine
2024;46(11):1499-1505
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the medication law of Professor Piao Bingkui, a national renowned TCM doctor, in treating lung cancer.Method:Medical records and TCM prescriptions of Professor Pu Bingkui for the treatment of lung cancer patients at Guang'anmen Hospital, Chinese Academy of Traditional Chinese Medicine were retrieved from the hospital information system from January 1, 2013 to December 30, 2023. Database was established with Excel 2019. Drug frequency and drug attribute statistics, association rule analysis, clustering analysis, factor analysis, and complex network analysis were conducted through the ancient and modern medical record cloud platform 2.3.7.Result:Totally 5 768 prescriptions were included, involving 193 kinds of Chinese materia medica. Seven kinds of Chinese materia medica' usage frequency exceeded 90%, which were Astragali Radix, Pseudostellariae Radix, Glehniae Radix, Platycodonis Radix, Citri Reticulatae Pericarpium, Angelicae Sinensis Radix and Coicis Semen. The main properties were neutral and warm, the main tastes were sweet and pungent, and the main meridians were lung, spleen, liver, stomach and kidney meridians. Three cluster groups were obtained by high-frequency medicine clustering. Eight factors were obtained by factor analysis. 48 medicinal pairs were obtained by association rule analysis, from which 6 core medicinal combinations were obtained. Complex network analysis showed that the core prescription was Astragali Radix, Pseudostellariae Radix, Angelicae Sinensis Radix, Glehniae Radix, Platycodonis Radix, Citri Reticulatae Pericarpium and Glycyrrhzzae Radix et Rhizoma.Conclusion:Professor Piao's clinical experience in treating lung cancer with TCM is based on the principle of strengthening healthy qi and eliminating pathogenic factors timely by flexible application of TCM methods as tonifying qi and lung, strengthening spleen and kidney, removing blood stasis and phlegm, clearing heat and detoxifying.
