A mendelian randomization study to explore the relationship between childhood narcolepsy and allergic rhinitis based on the theory of "phlegm-dampness impairing the spleen"
10.3760/cma.j.cn115398-20231024-00234
- VernacularTitle:基于“痰湿困脾”理论运用孟德尔随机化法探讨儿童发作性睡病与变应性鼻炎的因果关系
- Author:
Yuchen DAI
1
;
Weitao YE
;
Xinguang ZHANG
Author Information
1. 上海中医药大学附属市中医医院儿科，上海 200071
- Keywords:
Narcolepsy;
Hypersomnia;
Rhinitis, allergic;
Mendelian randomization
- From:
International Journal of Traditional Chinese Medicine
2024;46(11):1419-1425
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the causal relationship between childhood narcolepsy and allergic rhinitis using two-sample Mendelian randomization; To provide references for clinical prevention and treatment.Methods:Genetic variants closely related to narcolepsy were extracted from GWAS summary data as instrumental variables, with allergic rhinitis (AR) as the outcome variable. The narcolepsy data included 335 410 samples and 10 894 596 single nucleotide polymorphisms (SNPs). The AR data included 5 527 cases and 212 387 controls, with a total of 16 380 461 SNPs. Two-sample Mendelian randomization analyses were conducted using inverse variance weighted, weighted median, and MR-Egger regression methods mainly to evaluate the causal relationship between narcolepsy and AR with OR. Heterogeneity testing, pleiotropy assessment, and sensitivity analysis were used to evaluate the stability and reliability of the results.Results:A total of 42 SNPs were included as instrumental variables. It was found that the estimated effect of narcolepsy on AR was greater than 1 and with statistical significance [ OR(95% CI)=1.79(1.02,3.13), P=0.04]. Conclusions:There may be a positive causal relationship between narcolepsy and AR. "Phlegm-dampness impairing the spleen" is a common pathogenic mechanism between the two diseases.
