Optimization of the preparation process for Qinggan Liangxue Granules based on active components
10.3760/cma.j.cn115398-20240424-00282
- VernacularTitle:基于活性成分优化清肝凉血颗粒制备工艺研究
- Author:
Yan CHEN
1
;
Wenli YAN
;
Deyong ZHOU
;
Tuoxin LI
;
Heming FAN
;
Dongping LIU
Author Information
1. 北京市中医药研究所中药新药制剂研发中心 首都医科大学附属北京中医医院，北京 100010
- Keywords:
Psoriasis;
Qinggan Liangxue Granules;
Astilbin;
Paeoniflorin;
Orthogonal test;
Technology improving (TCD)
- From:
International Journal of Traditional Chinese Medicine
2024;46(11):1475-1479
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize the preparation process of Qinggan Liangxue Granules.Methods:The L 9 (3 4) orthogonal experimental design was used to investigate the effects of water addition, extraction time and extraction times on the extraction process of Qinggan Liangxue Granules by taking the transfer rate of astilbin and paeoniflorin as the indexes, so as to screen the optimal extraction process. The evaluation indexes of granule molding rate, water content, solubility and fluidity were used to compare the effect of finished products under different ratios of excipients and granulation conditions. Results:The optimal extraction process was to add 10 times the amount of water reflux extraction twice, each time 1.5 h; using wet granulation, the ratio of dry paste powder to base material was 4:1 ( m/ m), and the wetting agent was 95% ethanol. Conclusion:The preparation process of Qinggan Liangxue Granules is stable and feasible, which lays a foundation for further research and development and quality control.
