Overview of metabonomics integrated network pharmacology in the field of TCM
10.3760/cma.j.cn115398-20231205-00047
- VernacularTitle:中医药领域代谢组学整合网络药理学研究概况
- Author:
Xianqing HUANG
1
;
Bo ZHAO
;
Yang YANG
Author Information
1. 桂林医学院药学院2021级硕士研究生，桂林 541000
- Keywords:
TCM pharmacy;
Metabonomics;
Network pharmacology;
Application survey;
Review
- From:
International Journal of Traditional Chinese Medicine
2024;46(11):1526-1530
- CountryChina
- Language:Chinese
-
Abstract:
Metabonomics technology takes small molecular metabolites in organisms as the research object, analyzes the dynamic metabolic changes in organisms as a whole through modern technology, and explains its pathophysiological system in multiple dimensions. Network pharmacology is to systematically explore the correlation between drugs and diseases. The combination of network pharmacology and metabolomics is in line with the systematic and holistic thinking mode of TCM. At present, the integration technology of the two has certain applications in the research of TCM single drug, medicinal pair, material basis and mechanism of compound efficacy, toxic mechanism of Chinese materia medica, quality and composition of Chinese materia medica, and processing mechanism of Chinese materia medica. It can realize the effective components of the complex system of Chinese materia medica from the differential metabolites, and then find the core genes and target proteins of Chinese materia medica, and reveal the biological pathway of Chinese materia medica to prevent and treat diseases. It has the advantages of quickly and effectively identifying the efficacy and material basis of Chinese materia medica and clarifying its mechanism. However, the combination of the two lacks the acquisition of exogenous components and their related targets, and is prone to false positive results. The overall level is single and limited, so it needs to be further considered and improved.
