Research progress in the mechanism of Polygalae Radix in the treatment of Alzheimer's disease
10.3760/cma.j.cn115398-20240122-00263
- VernacularTitle:远志治疗阿尔茨海默病机制研究进展
- Author:
Li WU
1
;
Minghui DENG
;
Yongjiao LIU
;
Wei ZHUANG
Author Information
1. 北京市门头沟区中医医院药剂科，北京 102300
- Keywords:
Alzheimer disease;
Polygalae Radix;
Chemical composition;
Mechanism of action;
Research progress;
Review
- From:
International Journal of Traditional Chinese Medicine
2024;46(10):1383-1387
- CountryChina
- Language:Chinese
-
Abstract:
Polygalae Radix can calm the mind, enhance intelligence, dispel phlegm, and open the orifices. Often administered in combination with herbs such as Ginseng Radix et Rhizoma and Acori Tatarinowii Rhizoma, Polygalae Radix is frequently prescribed for the management of Alzheimer's disease. Rhizoma Polygalae and its chemical constituents play an important role in the prevention and treatment of Alzheimer's disease by acting on multiple targets and regulating multiple signaling pathways, such as inhibiting tau protein hyperphosphorylation, antioxidant stress, regulating cholinergic system, improving neuroinflammation, regulating β-amyloid abnormal metabolism, etc. Compound prescriptions composed of Polygalae Radix, such as Kaixin Powder, Yuanzhi Powder, Dihuang Decoction, Anshen Dingzhi Prescription, etc., also have anti-Alzheimer's disease effects and are widely used in clinical practice.
