Study on the causal relationship between gastroesophageal reflux disease and sleep disorder based on two sample Mendelian randomization
10.3760/cma.j.cn115398-20231212-00119
- VernacularTitle:基于两样本孟德尔随机化法探讨胃食管反流病与睡眠障碍因果关系的研究
- Author:
Jiaxin LIU
1
;
Jiao DUAN
;
Hui WU
;
Yingmin GU
;
Shaoxiang XIAN
Author Information
1. 广州医科大学附属中医医院五羊门诊部，广州 510130
- Keywords:
Sleep disorders;
Gastroesophageal reflux;
Mendelian randomization;
Gastric disharmony causing restless sleep;
Causal inference
- From:
International Journal of Traditional Chinese Medicine
2024;46(10):1277-1285
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the causal relationship between gastroesophageal reflux disease (GERD) and sleep disorder using Mendelian randomization (MR); To explore the diagnosis and treatment of sleep disorder with GERD by combining with the TCM theory that "gastric disharmony causing restless sleep".Methods:Genetic loci independent of each other and closely related to GERD were taken as instrumental variables by pooling data from a large-scale genome-wide association study. The causal relationship between GERD and sleep disorder was explored with Mendelian randomization methods, such as Inverse Variance Weighted (IVW), MR Egger, Weighted Median (WME), Simple Mode (SM), Weighted Mode (WM) and MR Multiple Effectiveness Residual Sum and Heteroscedasticity (MR-PRESSO) using OR as an evaluation index.Results:The results of the IVW method showed that GERD led to a 44.3% higher risk of developing sleep disorder ( P=4.96×10 -15, OR=1.443, 95% CI:1.317-1.582); horizontal pleiotropy was detected using the MR-Egger intercept, which was calculated to be P=0.646 ( P>0.05), proving that there was no horizontal pleiotropy in the results; Leave-one-out sensitivity test showed that the results were stable and there were no instrumental variables that strongly influenced the results. Conclusion:GRED is a risk factor for the development of sleep disorder, which is consistent with the TCM theory of "gastric disharmony causing restless sleep".
