Study on mechanism of compound Banlangen Granules for epidemic encephalitis B, hepatitis and parotitis based on UPLC-MS/MS and network pharmacology
10.3760/cma.j.cn115398-20231215-00163
- VernacularTitle:基于UPLC-MS/MS和网络药理学研究复方板蓝根颗粒治疗流行性乙型脑炎、肝炎及腮腺炎的作用机制
- Author:
Yuwei XIE
1
;
Zhiliang SUN
;
Youtian DENG
;
Yidong YANG
;
Yuan LI
;
Baoyi HONG
;
Guocheng FU
;
Yun WEI
;
Haigang CHEN
;
Pengfei YANG
;
Suyun LU
Author Information
1. 湖南农业大学动物医学院，长沙 410125
- Keywords:
Hepatitis;
Parotitis;
Epidemic encephalitis B;
Compound Banlangen granule;
UPLC-MS/MS;
Transitional components in blood;
Network pharmacology
- From:
International Journal of Traditional Chinese Medicine
2024;46(9):1178-1186
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To clarify the transitional components in the blood of compound Banlangen Granules; To explore the mechanism of drugs in the treatment of epidemic encephalitis B, hepatitis and parotitis.Methods:The transitional components in blood of compound Banlangen Granules were analyzed by ultra-high performance liquid chromatography-mass spectrometry (UPLC-MS/MS). The regulatory targets and pathways of compound Banlangen Granules in the treatment of epidemic encephalitis B, hepatitis and parotitis were analyzed based on UPLC-MS/MS and network pharmacology.Results:A total of 9 blood components were identified, of which 8 were prototype components, including sucrose, o-aminobenzoic acid, uridine, adenosine, guanosine, indole-3-acetonitrile-2 murine-S-β-D-glucopyranoside and salicylic acid. Through network pharmacological analysis, it was concluded that compound Banlangen Granules may treat epidemic encephalitis B, hepatitis and parotitis by regulating lipid and atherosclerosis, insulin resistance, IL-17 and other signal pathways.Conclusion:The 9 blood components of compound Banlangen Granules may treat epidemic encephalitis B, hepatitis and parotitis by regulating lipid and atherosclerosis, insulin resistance, IL-17 and other signal pathways.
