Clinical study on the treatment of chronic and prolonged non-infectious diarrhea in children (spleen and kidney yang deficiency type) with Pixu Jiuxie Prescription
10.3760/cma.j.cn115398-20230810-00100
- VernacularTitle:脾虚久泻方治疗小儿慢性迁延性非感染性腹泻脾肾阳虚证的临床研究
- Author:
Xinxin SHI
1
;
Shen HUANG
Author Information
1. 河南中医药大学儿科医学院，郑州 450000
- Keywords:
Diarrhea;
Non-infective;
Child;
Syndrome of yang deficiency of spleen and kidney;
Immunity
- From:
International Journal of Traditional Chinese Medicine
2024;46(9):1134-1139
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the clinical efficacy of Pixu Jiuxie Prescription in the treatment of chronic and prolonged non-infectious diarrhea (spleen kidney yang deficiency type) in children; To discuss its effects on immune function of patients.Methods:Randomized controlled trial study was conducted. 76 children with chronic and prolonged non-infectious diarrhea of spleen and kidney yang deficiency type who were treated at the Pediatric Clinic of the First Affiliated Hospital of Henan University of Traditional Chinese Medicine from December 2021 to February 2023 were selected as the research subjects. They were divided into two groups, with 38 cases in each group. The observation group was orally treated with Pixu Jiuxie Prescription, and the control group was orally treated with Diosmectite and Bifidobacterium Quadruple Viable Tablets. The treatment for both groups lasted for 30 d. Main symptoms, TCM syndromes, and TCM symptoms were scored before and after the treatment. Immunoassay was used to detect the levels of immunoglobulin IgM, IgA, and IgG, and clinical efficacy was evaluated.Results:After treatment, the total effective rate of the observation group was 94.74% (36/38), which was significantly higher than that of the control group 78.95% (30/38), with statistical significance ( χ2=14.05, P=0.003); Main symptoms: the number of stools in the observation group (1.86 ± 0.25 vs. 2.03 ± 0.49, t=7.14), and stool characteristics (1.62 ± 0.26 vs. 1.98 ± 0.37, t=8.26) were lower than those in the control group ( P<0.001). TCM syndrome: after treatment, the abdominal pain (0.68 ± 0.13 vs. 0.74 ± 0.37, t=7.38), abdominal distension (0.43 ± 0.25 vs. 0.75 ± 0.23, t=2.16), appetite (0.50 ± 0.10 vs. 0.88 ± 0.15, t=4.35), nausea and vomiting (0.18 ± 0.33 vs. 0.34 ± 0.36, t=6.53), fatigue and weakness (0.34 ± 0.24 vs. 0.43 ± 0.25, t=5.62), and dehydration (0.30 ± 0.11 vs. 0.68 ± 0.13, t=5.87) integration and the total score of (5.63 ± 4.33 vs. 9.63 ± 5.53, t=16.07) observation group were lower than those in the control group ( P<0.01 or P<0.05). TCM symptoms: after treatment, the scores of color deficiency (0.18 ± 0.33 vs. 0.24 ± 0.13, t=2.63), cold limbs (0.20 ± 0.11 vs. 0.28 ± 0.14, t=4.13), prolapse (0.08 ± 0.33 vs. 0.14 ± 0.37, t=3.64), and clear urine (0.23 ± 0.11 vs. 0.28 ± 0.13, t=8.27) in the observation group were lower than those in the control group ( P<0.01 or P<0.05). After treatment, the levels of immunoglobulin IgA [(0.52 ± 0.21) g/L vs. (0.40 ± 0.26) g/L, t=8.15], IgM [(8.76 ± 1.16) g/L vs. (7.68 ± 1.43) g/L, t=10.67], and IgG [(0.89 ± 0.39) g/L vs. (0.62 ± 0.33) g/L, t=12.15] in the observation group were higher than those in the control group ( P<0.01). Conclusion:Pixu Jiuxie Prescription can effectively improve the clinical symptoms and signs of children with chronic and prolonged non-infectious diarrhea with spleen kidney yang deficiency syndrome, enhance their immunity, and improve clinical efficacy.
