Transfusion Strategy of RhD-negative/variant Patients in the Korean Population.
- Author:
Hyung Seok YANG
1
;
Sejong CHUN
;
Sun Ah LEE
;
Jeong Ran KWON
;
Young Sill CHOI
;
Jun Nyun KIM
;
Duck CHO
Author Information
- Publication Type:Review
- Keywords: RHD; DEL; Transfusion; Genotyping
- MeSH: Asia; Blood Donors; Female; Humans; Korea; Prevalence
- From:Laboratory Medicine Online 2017;7(3):89-93
- CountryRepublic of Korea
- Language:Korean
- Abstract: The prevalence of RhD-negative individuals in the Korean population is approximately 0.15-0.30% and the supply of RhD-negative blood often faces potential shortage. Furthermore, 15-17% of serologically RhD-negative Korean individuals were revealed to be DEL variants and should be treated as RhD-positive when being considered as blood donors. This change is expected to result in a further shortage of RhD-negative blood supply, whereas surplus DEL variant blood stock is created. Therefore, it is now required to amend blood donation and supply policies, and transfusion strategies. In this review, a new transfusion strategy for patients with RhD-negative or variant blood in Korea is discussed, with particular interest in women of child-bearing age, patients with anti-D, and Asia type DEL (c.1227G>A) variants.
