Effects of modified Taohong Siwu Decoction on postoperative affected limb peripheral circulation and serum levels of TXB 2 and PGI 2 in patients with traumatic limb fractures
10.3760/cma.j.cn115398-20230720-00198
- VernacularTitle:改良桃红四物汤辅助治疗对创伤性四肢骨折术后患肢末梢循环及血栓素B 2、前列腺素I 2水平的影响
- Author:
Zhilin BAI
1
;
Xi ZHOU
;
Zhongqiu SA
Author Information
1. 昆山市中西医结合医院骨科，昆山 215300
- Keywords:
Fractures, bone;
Tao Hong Si Wu Tang;
Peripheral circulation;
Thromboxane B 2;
Prostaglandin I 2
- From:
International Journal of Traditional Chinese Medicine
2024;46(8):993-998
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effects of modified Taohong Siwu Decoction on peripheral circulation status of affected limbs and serum thromboxane B 2 (TXB 2) and prostacyclin (PGI 2) levels in patients with traumatic limb fractures after open reduction and internal fixation. Methods:Randomized controlled trial study was conducted. 70 patients with traumatic limb fractures who underwent open reduction and internal fixation in the hospital from February 2020 to February 2023 were set as observation subjects and divided into control group (34 cases) and observation group (36 cases) according to the order of hospitalization. The control group was given conventional method for treatment, and the observation group was given modified Taohong Siwu Decoction adjuvant therapy on the basis of the control group. The treatment for both groups lasted for 2 weeks. TCM symptoms scores were evaluated before and after treatment. Ankle brachial index (ABI) was detected using a Doppler blood flow detector. Color Doppler ultrasound was used to detect the inner diameter, blood flow, and deep veins of the affected limb; serum levels of TXB 2 and PGI 2 were detected by ELISA. Results:After treatment, the total effective rate of clinical efficacy was 91.67% (33/36) in observation group and 73.53% (25/34) in control group, with statistical significance ( P<0.05). After treatment, the observation group had lower scores for qi and blood stasis (2.13 ± 0.43 vs. 3.61 ± 0.96, t=5.85), tendon and bone injury (1.62 ± 0.41 vs. 2.74 ± 0.58, t=9.37), swelling and ecchymosis (1.15 ± 0.31 vs. 2.28 ± 0.52, t=1.12), and liver and kidney deficiency (1.52 ± 0.24 vs. 2.15 ± 0.36, t=8.66) compared to the control group ( P<0.001); after treatment, the ABI (0.83 ± 0.03 vs. 0.74 ± 0.02, t=14.68), vascular diameter [(0.48 ± 0.13) mm vs. (0.42 ± 0.11) mm, t=2.08], and blood flow velocity [(60.24 ± 15.46) cm/s vs. (52.15 ± 12.11) cm/s, t=2.41] in the observation group were higher than those in the control group ( P<0.01 or P<0.05). After treatment, the serum TXB 2 levels [(140.76 ± 16.64) ng/L vs. (168.39 ± 25.28) ng/L, t=5.37] and TXB 2/PGI 2 (6.67 ± 1.24 vs. 9.33 ± 1.69, t=7.54) in the observation group were lower than those in the control group ( P<0.01); the level of PGI 2 [(21.27 ± 2.24) ng/L vs. (18.71 ± 1.79) ng/L, t=5.26] was higher in the control group ( P<0.01). The incidence of deep vein thrombosis after treatment in the observation group was 19.44% (7/36), while in the control group it was 44.12% (15/34), with statistical significance ( χ 2=4.94, P=0.026). Conclusion:Modified Taohong Siwu Decoction adjuvant therapy can enhance the clinical efficacy of patients with traumatic limb fractures after open reduction and internal fixation, relieve the TCM symptoms, improve the peripheral circulation status of affected limbs, reduce the postoperative hypercoagulability and prevent the deep venous thrombosis formation.
