Study on the medication law of TCM compounds used in the treatment of non-small cell lung cancer
10.3760/cma.j.cn115398-20231116-00188
- VernacularTitle:中药复方治疗非小细胞肺癌用药规律研究
- Author:
Ying CHEN
1
;
Ziming ZHANG
;
Yong ZHU
;
Yuan GAO
;
Shina ZHANG
;
Boyang SHENG
;
Junfeng YAN
Author Information
1. 湖南中医药大学2021级硕士研究生，长沙 410208
- Keywords:
Carcinoma, non-small-cell lung;
TCM compound;
Medication rule;
Data mining
- From:
International Journal of Traditional Chinese Medicine
2024;46(5):642-649
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the medication law of TCM compounds used in the treatment of non-small cell lung cancer (NSCLC).Methods:Clinical literature about TCM compounds in the treatment of NSCLC was retrieved from CNKI, Wanfang Data, PubMed and Web of Science core collection database from January 1st, 2003 to May 1st, 2023. The Python and the ancient and modern medical record cloud platform V2.3.7 were used to analyses frequency statistics and properties, and clustering analysis, factor analysis and association rule analysis were performed.Results:A total of 866 articles were included, with 660 effective TCM compounds, 647 kinds of Chinese materia medica. There were 36 kinds of high-frequency Chinese materia medica, such as Astragali Radix, Atractylodis Macrocephalae Rhizoma and Poria; the efficacy categories of Chinese materia medica mainly included tonics and phlegm resolving cough relieving and asthma relieving drugs. Cluster analysis obtained 4 clusters, factor analysis extracted 11 common factors, and association rule analysis obtained 37 highly supported combinations of Chinese materia medica. The most reliable triple drug combination among them was Astragali Radix-Atractylodis Macrocephalae Rhizoma-Hedyotis diffusa willd, and the double drug combination was Astragali Radix-Ligustri Lucidi Fructus.Conclusion:TCM for the treatment of NSCLC mainly focuses on strengthening the healthy qi, clearing heat, resolving phlegm and detoxifying toxins, supplemented by tonifying qi and activating blood circulation, dispelling dampness and resolving phlegm.
