Extraction process optimization for preparation of Ziyin Qinggu Pills by overall desirability and response surface methodology

VernacularTitle:总评归一法结合响应面法优化滋阴清骨丸提取工艺
Author: Runliang YIN ¹ ; Xuemei WANG ; Xixiang LI ; Qin SU ; Jianliang WANG
Author Information

1. 甘肃中医药大学药学院，兰州　730000
Keywords: Extraction; Zingy Qinggu Pills; Central composite design-response surface methodology
From: International Journal of Traditional Chinese Medicine 2024;46(5):631-636
CountryChina
Language:Chinese
Abstract: Objective:To optimize the extraction process of Ziyin Qinggu Pills.Methods:The solvent amount, extraction time and soaking time were taken as the influencing factors, and the overall desirability (OD) of the contents of timosaponin BⅡ, paeoniflorin, calycosin 7-O-glucoside, liquiritin and the dry extract yield were taken as the evaluation indexes, so that the optimal extraction process of Ziyin Qinggu Pills was optimally selected by the centralized composite design-response surface method.Results:The optimal extraction process of Ziyin Qinggu Pills was as follows: extraction time of 115 min, soaking time of 26 min, solvent volume of 10 times, and extraction twice.Conclusion:The optimal extraction process is reasonable, stable and reliable, which can provide the basis and foundation for the extraction process and further molding process of Ziyin Qinggu Pills.