Progress in the study of the pregnane X receptor in drug resistance in breast cancer

VernacularTitle:孕烷X受体在乳腺癌耐药中的研究进展
Author: Xiaoxu HAN ¹ ; Nan ZHANG ; Shuai LIU
Author Information

1. 山东第一医科大学研究生部，济南　250117
Keywords: Breast neoplasms; Pregnane X receptor; Drug resistance
From: Journal of International Oncology 2024;51(9):590-594
CountryChina
Language:Chinese
Abstract: The pregnane X receptor (PXR) is a crucial regulator of cytochrome P-450 (CYP450) expression. It is involved in oxidative stress, steroid and bile acid metabolism, inflammatory response, apoptosis, cell proliferation and other biological behaviors, and also participates in the metabolism, transport and clearance of chemotherapy drugs. After activation, PXR can affect chemotherapy drug resistance of breast cancer through genetic variation and epigenetic modification, regulation of apoptosis, and participation in phosphorylation/dephosphorylation. It may be a potential therapeutic target for patients with breast cancer resistance.