Relationship between Vav3 and malignant tumors

VernacularTitle:Vav3与恶性肿瘤的关系
Author: Xuebing SHI ¹ ; Jing WU ; Wenxia DENG
Author Information

1. 安徽省铜陵市人民医院胸部肿瘤病区，铜陵　244000
Keywords: Neoplasms; Vav guanine nucleotide exchange factor 3
From: Journal of International Oncology 2024;51(9):585-589
CountryChina
Language:Chinese
Abstract: Vav guanine nucleotide exchange factor 3 (Vav3) protein is one of the guanine nucleotide exchange factors of the Rho family GTPases. It is encoded by the proto-oncogene Vav3 and is involved in the regulation of cell proliferation and apoptosis, differentiation, migration, etc. In recent years, Vav3 has been closely related to the development of a variety of malignant tumors. In glioma, breast cancer, non-small cell lung cancer, gastric cancer, pancreatic cancer, colorectal cancer, prostate cancer, ovarian cancer, osteosarcoma and acute leukemia, the expression of Vav3 is elevated to varying degrees, and it participates in regulating multiple signaling pathways, which promotes the progression of tumors and affects the prognosis of patients. Therefore, Vav3 is expected to be a potential therapeutic target for these malignant tumors.