Research progress on intestinal flora and non-surgical treatment of the colorectal cancer
10.3760/cma.j.cn371439-20240429-00065
- VernacularTitle:肠道菌群与结直肠癌非手术治疗的相关研究进展
- Author:
Fan GAO
1
;
Ping WANG
;
Chao DU
;
Yanliu CHU
Author Information
1. 山东第二医科大学临床医学院，潍坊 261000
- Keywords:
Colorectal neoplasms;
Gastrointestinal microbiome;
Drug therapy;
Radiotherapy;
Immunotherapy
- From:
Journal of International Oncology
2024;51(6):376-381
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, intestinal flora has gradually become the focus of research on the treatment of malignant neoplasms. Intestinal opportunistic pathogens (such as Fusobacterium nucleatum, Bacteroides fragilis), intestinal probiotics (such as Clostridium butyricum, Lactic acid bacteria) and intestinal pathogenic bacteria (such as Salmonella, Shigella) can affect the efficacy and related adverse reactions of radiotherapy, chemotherapy and immunotherapy for the colorectal cancer (CRC) by influencing signaling pathways, modulating autophagy, regulating immune response, producing metabolites and toxins, and transplanting fecal bacteria. At the same time, it provides a large number of potential targets for targeted therapy of the CRC. Further research on the relationship between intestinal flora and non-surgical treatment of the CRC can provide references for basic and clinical research of non-surgical treatment of the CRC.
