Role of PFDN and its subunits in tumorigenesis and tumor development
10.3760/cma.j.cn371439-20240218-00060
- VernacularTitle:PFDN及其亚基在肿瘤发生发展中的作用
- Author:
Zehao GUO
1
;
Junwang ZHANG
Author Information
1. 山西医科大学第二医院消化内科，太原 030000
- Keywords:
Neoplasms;
Carcinogenesis;
Prefoldin
- From:
Journal of International Oncology
2024;51(6):350-353
- CountryChina
- Language:Chinese
-
Abstract:
Prefoldin (PFDN) acts as a co-companion protein to stabilize newly synthesized peptides and prevent protein misfolding and aggregation. PFDN plays an important role in cytoskeleton formation. PFDN is upregulated in glioma, breast cancer, lung cancer, gastric cancer, liver cancer, colorectal cancer and other tumor tissues and is closely linked with the proliferation and migration of tumor cells. A deeper understanding of the role of PFDN in tumorigenesis and development may provide new ideas and insights for PFDN in preventing or reversing tumor progression.
