Progress of ferroptosis-related mechanisms in osteosarcoma
10.3760/cma.j.cn371439-20240304-00052
- VernacularTitle:铁死亡相关机制在骨肉瘤中的应用进展
- Author:
Peixin WANG
1
;
Jun ZHAO
;
Shihong XU
;
Zhaoyang JIANG
;
Xiaoqiang WANG
;
Hongjuan YANG
Author Information
1. 甘肃中医药大学中医临床学院，兰州 730000
- Keywords:
Osteosarcoma;
Ferroptosis;
Molecular targeted therapy
- From:
Journal of International Oncology
2024;51(5):308-311
- CountryChina
- Language:Chinese
-
Abstract:
Osteosarcoma is a common primary malignant bone tumor with highly aggressive and distal metastasis and poor prognosis. Abnormal metabolism of iron, an essential nutrient with electron-exchange capacity and an important participant in cellular activities, is closely associated with the progression of osteosarcoma. Ferroptosis has been shown to regulate osteosarcoma progression and play an important role in the treatment of osteosarcoma. Exploring the application of relevant molecular mechanisms of ferroptosis in osteosarcoma and the current status of pharmacological intervention may provide new strategies for the treatment of osteosarcoma.
