Current status and progress of liver transplantation for intrahepatic cholangiocarcinoma
10.3760/cma.j.cn115396-20240628-00201
- VernacularTitle:肝移植治疗肝内胆管癌的现状与进展
- Author:
Yafei GUO
1
;
Shaobo ZHANG
;
Hao ZHENG
;
Shugeng ZHANG
Author Information
1. 中国科学技术大学附属第一医院器官移植中心，合肥 230036
- Keywords:
Liver transplantation;
Bile duct neoplasms;
Hepatectomy;
Intrahepatic cholangiocarcinoma;
Surgical treatment;
Prognostic analysis
- From:
International Journal of Surgery
2024;51(8):554-559
- CountryChina
- Language:Chinese
-
Abstract:
Intrahepatic cholangiocarcinoma is a highly aggressive type of liver cancer, and traditional hepatectomy has shown limited efficacy. Recently, liver transplantation has garnered attention as a potential therapeutic option. The criteria for selecting patients for liver transplantation have been a focal point of research. For early-stage patients, liver transplantation can offer favorable survival rates; however, for those with advanced or locally advanced cases that are not amenable to conventional resection, the efficacy of liver transplantation remains to be further validated. Given the scarcity of donors, living donor liver transplantation and extended criteria donor liver transplantation are gradually being applied to patients with intrahepatic cholangiocarcinoma. Additionally, the advent of adjuvant and neoadjuvant therapies has brought hope to some advanced or conventionally unresectable intrahepatic cholangiocarcinoma patients who undergo liver transplantation. Particularly, the use of immune checkpoint inhibitors may serve as a bridging or adjunct therapy for liver transplantation in the future. The development and exploration of autologous and xenogeneic liver transplantation have introduced new perspectives. This paper provides a review of the current status and progress of liver transplantation in the treatment of intrahepatic cholangiocarcinoma based on relevant literature.
