Role of BRAF gene mutation detection in thyroid nodules in guiding total thyroid cancer surgery

VernacularTitle:甲状腺结节 BRAF基因突变检测在指导甲状腺癌全切手术中的作用
Author: Jie LIU ¹ ; Wenqing CAI ; Dongxu YUAN ; Xiaoli LIU
Author Information

1. 吉林大学中日联谊医院甲状腺外科，长春　130033
Keywords: Thyroid neoplasms; Thyroidectomy; Review; BRAF
From: International Journal of Surgery 2024;51(5):349-354
CountryChina
Language:Chinese
Abstract: Thyroid carcinoma is a common malignant tumor of the endocrine system and its incidence has increased significantly in recent years. Surgery is the most important initial treatment for thyroid cancer, but total thyroidectomy increases the risk of postoperative hyponatremia and recurrent laryngeal nerve injury while prolonging the disease-free survival of patients, decreasing the risk of disease recurrence and reducing residual lesions. Therefore, how to make the best surgical decision based on preoperative findings is still controversial. V-raf murine sarcoma viral oncogene homolog B1 ( BRAF), as one of the common genetic mutations in thyroid malignant tumors, is closely related to the degree of malignancy and prognosis of the tumor. Preoperative BRAF gene testing can help determine the aggressive pathological features of thyroid tumors and provide scientific guidance for clinicians to decide the scope of surgical resection.This article reviews the guiding role of BRAF gene mutation detection results in total thyroid cancer resection.