Meta-analysis of the prognostic impact of surgical resection of gastroenteropancreatic neuroendocrine tumors with liver metastases
10.3760/cma.j.cn115396-20240317-00080
- VernacularTitle:手术切除对胃肠胰神经内分泌肿瘤伴肝转移预后影响的Meta分析
- Author:
Wei WEI
1
;
Lei SHEN
;
Kun LIU
;
Ruibo DING
;
Yechuan XU
Author Information
1. 安徽医科大学第一附属医院肝胆胰外科，合肥 230000
- Keywords:
Carcinoma, neuroendocrine;
Digestive system neoplasms;
Surgical procedures, operative;
Liver resection;
Treatment outcome
- From:
International Journal of Surgery
2024;51(5):314-318
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of surgical resection on the prognosis of patients with gastroenteropancreatic neuroendocrine tumors with liver metastases.Methods:Through meta-analysis, this study used "Gastroenteropancreatic neuroendocrine tumor" "liver metastasis" "liver resection" and "primary tumor". "resection" were English keywords, and the search period was from 1 January 2000 to 30 July 2022. CNKI, Pubmed, Embase, and the Cochrane library were searched for studies on liver metastases from gastroenteropancreatic neuroendocrine tumors. After quality evaluation of the included studies, a meta-analysis was performed using Review Manager 5.4.1 and STATA 17 software.Results:Complying with the standard total of 16 papers, systematic analysis showed that compared with non-surgical treatment, the mortality rate of patients treated surgically (primary tumor resection, liver metastasectomy, primary tumor resection + liver metastasectomy) was significantly lower, and the difference was statistically significant ( P<0.01); for patients with resectable liver metastases, primary tumor resection alone versus primary tumor resection + liver metastase for patients with resectable liver metastases, 5-year overall survival was statistically significant ( P<0.01) compared with primary tumor resection + liver metastases resection, and their primary tumor resection + liver metastases resection prolonged the median survival; for patients with liver metastases, 5-year survival was statistically different from the size of liver metastases to liver volume ( P<0.01), and metastases greater than 50% had poor prognosis. Conclusion:Surgical treatment can significantly improve the survival time of patients with neuroendocrine tumors with liver metastases, and resection of only the primary site or metastases is also effective in improving the prognosis of patients.
