Development and application of liver organoid technology
10.3760/cma.j.cn115396-20240123-00017
- VernacularTitle:肝脏类器官技术的发展与应用
- Author:
Jicai WANG
1
;
Guangquan ZHANG
;
Fenfang WU
;
Xianjie SHI
Author Information
1. 中山大学附属第八医院肝胆胰外科，深圳 518033
- Keywords:
Organoids;
Liver diseases;
Stem cells;
Regenerative medicine;
Precision medicine
- From:
International Journal of Surgery
2024;51(4):271-277
- CountryChina
- Language:Chinese
-
Abstract:
Derived from embryonic stem cells, induced pluripotent stem cells, or adult stem cells, liver organoids not only mimic the tissue structure, gene expression patterns, and genetic characteristics of in vivo liver but also demonstrate significant potential in simulating liver diseases, drug screening, precision medicine, and regenerative medicine. This technology is particularly valuable in modeling various conditions such as malignant liver tumors, liver fibrosis, cirrhosis, viral hepatitis, and a range of genetic and metabolic liver diseases. However, challenges remain in enhancing the derivation and proliferation efficiency of organoids, constructing immune microenvironments, developing functional vascular networks, and achieving standardization and automation in the organoid preparation process. Looking forward, with continued technological advancements and innovations, these issues are expected to be resolved, paving the way for liver organoids to play a more substantial role in clinical and research applications, ultimately contributing significantly to public health. This review comprehensively explores the development and extensive applications of liver organoid technology in the field of biomedical science. The aim is to inform subsequent research.
