Progress in the clinical application of ex vivo machine perfusion in liver transplantation
10.3760/cma.j.cn115396-20240220-00042
- VernacularTitle:体外机械灌注在肝移植中的临床应用进展
- Author:
Ruiquan ZHOU
1
;
Haidong TAN
Author Information
1. 中日友好医院肝脏移植中心（肝胆胰外科二部），北京 100029
- Keywords:
Liver transplantation;
Hemoperfusion;
Organ preservation;
Ischemia-free liver transplantation;
Static cold storage
- From:
International Journal of Surgery
2024;51(4):217-222
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, liver transplantation in China has developed rapidly, and the demand for donor organs is increasing. Faced with the dilemma of organ shortage, using marginal donors or expanding the criteria for standard donors is one of the practical methods to solve the problem. Compared with static cold storage, ex vivo machine perfusion in the liver transplantation can evaluate and repair the vitality of the grafts. The advantages of machine perfusion have been widely recognized when extended criteria donor organs were transplanted. Ex vivo mechanical perfusion strategies mainly include hypothermic(oxygenated) machine perfusion, normothermic machine perfusion, controlled oxygenated rewarming perfusion and ischemic-free liver transplantation, and different machine perfusion strategies have their own characteristics and advantages. This article reviews the development process and the characteristics of various machine perfusion strategies. The future development and application of machine perfusion were prospected in order to promote the widespread application of this technology.
