Research progress in engineered white blood cell membrane-coated nanocarriers for the treatment of inflammatory-related diseases
10.3760/cma.j.cn121382-20240407-00509
- VernacularTitle:工程化白细胞膜包被纳米载体用于炎症性相关疾病治疗的研究进展
- Author:
Qi SU
1
;
Zujian FENG
Author Information
1. 中国医学科学院 北京协和医学院生物医学工程研究所，天津 300192
- Keywords:
Cell membrane;
White blood cell;
Nanocarriers;
Inflammatory targeting;
Biological neutralization;
Immunomodulation
- From:
International Journal of Biomedical Engineering
2024;47(5):472-476
- CountryChina
- Language:Chinese
-
Abstract:
White blood cell, as a type of immune cell, plays a crucial role in fighting against bacterial infections, inflammatory diseases, and cancer. White blood cell membrane-coated nanocarriers (WBC-NCs) inherit the source cell membrane antigens while exhibiting great potential for inflammation-related therapies. In this review, the preparation of WBC-NCs and the strategies of engineered white blood cell membrane were summarized, which involved utilizing physical engineering, chemical modifications, and bioengineering to endow natural cell membranes with diverse functionalities. The functions of engineered WBC-NCs were also summarized in the treatment of inflammatory-related diseases through drug delivery, biological neutralization, and immunomodulation. In general terms, engineered WBC-NCs have emerged as a platform with potential for medical applications.
