Research progress of mRNA delivery system in central nervous system diseases
10.3760/cma.j.cn121382-20240401-00413
- VernacularTitle:mRNA递送系统在中枢神经系统疾病方面的研究进展
- Author:
Zihao LIN
1
;
Yue WU
;
Ying MENG
;
Zhongxiong FAN
Author Information
1. 新疆大学生命科学与技术学院，生物学国家级实验教学示范中心，新疆生物资源基因工程重点实验室，乌鲁木齐 830017
- Keywords:
mRNA;
Nanodrug delivery system;
Central nervous system diseases;
Lipid carrier;
Protein mRNA complex;
Polymeric carrier;
Mixed carrier
- From:
International Journal of Biomedical Engineering
2024;47(4):395-405
- CountryChina
- Language:Chinese
-
Abstract:
The successful development of messenger RNA (mRNA) vaccines provides a new strategy for mRNA-based therapies for the treatment of various diseases. Nanomaterials have attracted much attention in nanomedicine due to their unique physicochemical properties. Therefore, combining mRNA therapy with nanomaterial-based delivery systems to form a unique mRNA delivery system for the treatment of various central nervous system diseases is undoubtedly an innovative new therapeutic strategy. In this review paper, the advances in delivery strategies for mRNA, including lipid carriers, protein mRNA complexes, polymeric carriers, and mixed carriers, were summarized, and their applications in central nervous system diseases therapeutic such as mRNA vaccines and genome editing in combination with mRNA therapy were described.
