Research progress of biological action of SMPD3 in tumor diseases
10.3760/cma.j.cn121382-20240207-00312
- VernacularTitle:SMPD3在肿瘤中生物学作用的研究进展
- Author:
Jingfei ZHAO
1
;
Luyong YANG
;
Bai RUAN
;
Jianyong ZHENG
Author Information
1. 空军军医大学第一附属医院（西京医院）空勤科，西安 710032
- Keywords:
Sphingomyelin phosphodiesterase 3;
Neutral sphingomyelinase 2;
Tumour;
Ceramide
- From:
International Journal of Biomedical Engineering
2024;47(3):281-287
- CountryChina
- Language:Chinese
-
Abstract:
Sphingomyelin phosphodiesterase 3 (SMPD3) encodes neutral sphingomyelinase 2 (nSMase2), which plays an important role in tumor development as a key enzyme regulating cell growth variation and inducing apoptosis with the important messenger molecule ceramide. On one hand, the common epigenetic alteration of SMPD3 methylation mediates carcinogenesis through the disruption of gene expression by regulating cell proliferation, differentiation, and apoptosis. Meanwhile, SMPD3 also induces apoptosis and cell cycle arrest in tumor cells through its hydrolysis products. On the other hand, SMPD3 is also closely related to pro-cancer processes such as exosome secretion, inflammatory response, and tumor cell proliferation. In this paper, the biological action of SMPD3 in tumor diseases was reviewed to enhance the understanding of the role of SMPD3 in the development of different tumors and provide broader ideas for basic research and clinical diagnosis and treatment of tumor diseases.
