Associations of serum low-density lipoprotein cholesterol with hematoma enlargement, early neurological deterioration, and outcome in patients with acute spontaneous intracerebral hemorrhage
10.3760/cma.j.issn.1673-4165.2024.07.005
- VernacularTitle:血清低密度脂蛋白胆固醇与急性自发性脑出血患者血肿增大、早期神经功能恶化和转归的相关性
- Author:
Ting LAN
1
;
Xiwa HAO
;
Lin LYU
;
Cuiqin ZHANG
;
Hongmei QIAO
;
Bobo ZHANG
;
Yongming CHEN
;
Qidi BO
;
Meiyou YAN
;
Hui LYU
;
Jingfen ZHANG
Author Information
1. 内蒙古医科大学包头临床医学院，包头 014040
- Keywords:
Cerebral hemorrhage;
Hematoma;
Cholesterol, LDL;
Tomography, X-ray computed;
Disease progression;
Treatment outcome
- From:
International Journal of Cerebrovascular Diseases
2024;32(7):506-511
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate associations of serum low-density lipoprotein cholesterol (LDL-C) with hematoma enlargement, early neurological deterioration (END), and outcome in patients with acute spontaneous intracerebral hemorrhage (ICH).Methods:"A multi-center registration study for spontaneous intracerebral hemorrhage in Inner Mongolia" (registration number: ChiCTR2000029494) database was used to include patients with ICH who completed their first head CT scan within 6 hours after onset, underwent blood lipid examination, CT follow-up within 24 hours of onset, and accurately measured hematoma volume using 3D Slicer software between June 2020 and September 2022. HE was defined as hematoma volume increasing >33% or >6 ml at 24 hours, or ventricular hematoma volume increasing ≥1 ml compared to the baseline. END was defined as an increase of ≥4 in the National Institutes of Health Stroke Scale (NIHSS) score from the baseline or death within 24 hours after onset. The follow-up was conducted at 3 months after onset, and the modified Rankin Scale score >2 was defined as poor outcome. Multivariate logistic analysis was used to determine the independent correlation between LDL-C and HE, END, and outcome. Results:A total of 338 patients with ICH were enrolled, including 206 males (60.9%). LDL-C was 2.39±1.22 mmol/L. Eighty-eight patients (26.0%) developed HE, 67 (19.8%) developed END, and 162 (47.9%) had poor outcome at 3 months. Multivariate logistic analysis showed that after adjusting for confounding factors, there was a significant independent negative correlation between LDL-C and HE (odds ratio 0.312, 95% confidence interval 0.208-0.467; P<0.001) and END (odds ratio 0.408, 95% confidence interval 0.275-0.606; P<0.001), but not with the outcome at 3 months. Conclusion:Lower LDL-C is associated with HE and END in patients with ICH, but not with the outcome.
