Role and mechanism of stimulator of interferon genes in cerebral ischemia
10.3760/cma.j.issn.1673-4165.2024.06.011
- VernacularTitle:干扰素基因刺激因子在脑缺血中的作用及其机制
- Author:
Shanshan DUAN
1
;
Meiyan CHEN
;
En XU
Author Information
1. 广州医科大学神经科学研究所，广州医科大学附属第二医院神经内科，广州 510260
- Keywords:
Brain ischemia;
Interferons;
Ferroptosis;
Autophagy;
Inflammation;
Oxidative stress;
Stimulator of interferon genes
- From:
International Journal of Cerebrovascular Diseases
2024;32(6):460-465
- CountryChina
- Language:Chinese
-
Abstract:
Stimulator of interferon genes (STING) is a transmembrane protein located on the endoplasmic reticulum that plays an important role in innate immune regulation. After cerebral ischemia, STING exacerbates neuronal death by activating autophagy, triggering inflammation, and inducing oxidative stress. It can also destroy the integrity of the blood-brain barrier via neutrophil extracellular traps (NETs), thereby exacerbating ischemic brain injury. Therefore, elucidating the biological characteristics of STING and its role and mechanism in cerebral ischemia is of great significance for the development of therapeutic drugs for cerebral ischemia.
