Peripheral immune cells and outcome of patients with acute ischemic stroke
10.3760/cma.j.issn.1673-4165.2024.06.007
- VernacularTitle:外周免疫细胞与急性缺血性卒中患者转归
- Author:
Honghong JI
1
;
Mengmeng WANG
;
Lingyu ZHANG
;
Pengfei WANG
;
Zhen ZHANG
Author Information
1. 滨州医学院第二临床医学院，烟台 264003
- Keywords:
Ischemic stroke;
Neutrophils;
T-Lymphocytes;
Killer cells, natural;
Inflammation;
Blood-brain barrier;
Prognosis
- From:
International Journal of Cerebrovascular Diseases
2024;32(6):440-444
- CountryChina
- Language:Chinese
-
Abstract:
After onset of acute ischemic stroke, nerve cells undergo ischemic necrosis, release endogenous damage related pattern molecules, which activate microglia and astrocytes, and lead to immune inflammatory responses. At the same time, it attracts and chemotactically guide peripheral blood immune cells to infiltrate brain tissue through the damaged blood-brain barrier, further exacerbating brain injury. Studies have shown that the peripheral blood immune cells are closely associated with the outcome of acute ischemic stroke. This article summarizes the mechanism of peripheral immune cells in ischemic brain injury, their correlation with clinical outcome, and possible intervention measures.
