White matter hyperintensity penumbra
10.3760/cma.j.issn.1673-4165.2024.05.012
- VernacularTitle:脑白质高信号半暗带
- Author:
Tan LI
1
;
Mengfan YE
;
Xiuying CAI
;
Qi FANG
Author Information
1. 苏州大学附属第一医院神经内科，苏州 215006
- Keywords:
Cerebral small vessel diseases;
White matter;
Magnetic resonance imaging;
Diffusion tensor imaging;
Cognition disorders;
Depression
- From:
International Journal of Cerebrovascular Diseases
2024;32(5):380-385
- CountryChina
- Language:Chinese
-
Abstract:
White matter hyperintensities (WMHs) are one of the main imaging biomarkers of cerebral small vessel disease (CSVD). With the development of neuroimaging technology, the WMH penumbra (WMH-P) has gradually become a research hotspot. WMH-P refers to the area of brain tissue microstructural integrity destruction or reduced blood flow perfusion around WMH lesions, which is not visible on conventional MRI sequences. It is not only a risk factor for the progression of WMHs, but also associated with clinical symptoms such as cognitive impairment and gait abnormalities in patients with CSVD, and is considered a new potential and reversible therapeutic target.
