Impact of overweight or obesity on outcome in patients with hypertensive intracerebral hemorrhage
10.3760/cma.j.issn.1673-4165.2024.05.006
- VernacularTitle:超重或肥胖对高血压性脑出血患者转归的影响
- Author:
Yue ZHANG
1
;
Zhiwei XU
;
Yuxin LI
;
Dapeng DAI
;
Aimin LI
Author Information
1. 徐州医科大学附属连云港医院神经外科，连云港 222000
- Keywords:
Cerebral hemorrhage;
Obesity;
Overweight;
Body mass index;
Obesity paradox;
Treatment outcome;
Risk factors
- From:
International Journal of Cerebrovascular Diseases
2024;32(5):349-353
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between overweight or obesity defined by body mass index (BMI) and functional outcome in patients with hypertensive intracerebral hemorrhage (HICH).Methods:Patients with HICH admitted to the Department of Neurosurgery, the First People's Hospital of Lianyungang from October 2020 to February 2022 were included retrospectively. According to BMI, they were divided into underweight or normal group (<24 kg/m 2) and overweight or obese group (≥24 kg/m 2). At one year after onset, the functional outcome were evaluated using the modified Rankin Scale. 0-2 was defined as good outcome, while >2 were defined as poor outcome. Cox proportional hazards regression model was used to analyze the correlation between BMI and the outcome of patients. Results:A total of 394 patients with HICH were enrolled, including 263 males (66.8%), aged 60.2±12.0 years. At one year after onset, 145 patients (36.8%) had poor outcome and 54 (13.7%) died. Compared with the underweight or normal group, the overweight or obese group had a higher proportion of previous type 2 diabetes history, as well as higher baseline diastolic blood pressure, low-density lipoprotein cholesterol and liver enzyme levels, better early outcome after discharge, and lower mortality at 1 year (all P<0.05). Multivariate analysis showed that the overweight or obese group had significantly better functional outcome compared to the underweight or normal group (hazard ratio 0.598, 95% confidence interval 0.419-0.854; P=0.005), but there was no statistically significant difference in all-cause mortality risk (hazard ratio 1.201, 95% confidence interval, 0.462-3.126; P=0.707). Conclusion:The overweight or obese patients with HICH have significantly better functional outcome at one year after onset, indicating that the obesity paradox also exists in patients with HICH.
