Risk factors for in-stent restenosis in patients with severe symptomatic intracranial carotid stenosis
10.3760/cma.j.issn.1673-4165.2024.04.003
- VernacularTitle:重度有症状颅内段颈动脉狭窄患者支架内再狭窄的危险因素
- Author:
Xiuyu WANG
1
;
Huakun LIU
;
Jianfeng CHU
Author Information
1. 济宁医学院临床医学院，济宁 272000
- Keywords:
Carotid stenosis;
Intracranial arteriosclerosis;
Stents;
Treatment outcome;
Risk factors
- From:
International Journal of Cerebrovascular Diseases
2024;32(4):254-259
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate risk factors for in-stent restenosis (ISR) after percutaneous transluminal angioplasty and stenting (PTAS) in patients with severe symptomatic intracranial carotid stenosis.Methods:Consecutive patients with severe symptomatic intracranial carotid stenosis underwent PTAS in the Department of Neurology, Jining First People's Hospital from December 2021 to June 2023 were retrospectively included. Clinical and procedure related data were collected, and periprocedural complications were recorded. Imaging follow-up was used to evaluate ISR after 6 months. Multivariate logistic regression analysis was used to determine independent risk factors for ISR. Results:A total of 73 patients were enroled, including 45 males (61.6%), aged 61.49±7.78 years. The median follow-up time was 8 months (interquartile range, 7-9 months; range, 6-10 months), with 19 cases (26.0%) experiencing ISR, of which 1 (1.4%) had symptomatic ISR. Multivariate logistic regression analysis showed that the higher degree of residual stenosis immediately after procedure (odds ratio [ OR] 1.102, 95% confidence interval [ CI] 1.004-1.209; P=0.040), accompanied by moderate to severe cerebrovascular stenosis in other areas ( OR 6.638, 95% CI 1.106-39.835; P=0.038) and low preprocedural white blood cell count ( OR 0.541, 95% CI 0.308-0.952; P=0.033) were the independent risk factors for ISR. Conclusion:The higher degree of residual stenosis immediately after procedure, accompanied by moderate to severe cerebrovascular stenosis in other areas, and lower preprocedural white blood cell count are the risk factors for the occurrence of ISR after PTAS in patients with severe intracranial carotid stenosis.
