Role of microglial metabolic reprogramming in ischemic stroke
10.3760/cma.j.issn.1673-4165.2024.03.007
- VernacularTitle:小胶质细胞代谢重编程在缺血性卒中中的作用
- Author:
Wenhua NING
1
;
Wenting LI
;
Yiying LIU
;
Haiming WANG
Author Information
1. 郑州大学第一附属医院康复医学科，郑州 450052
- Keywords:
Ischemic stroke;
Brain ischemia;
Microglia;
Inflammation
- From:
International Journal of Cerebrovascular Diseases
2024;32(3):197-201
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, researches have shown that microglia drive their phenotype polarization through energy and substance metabolism reprogramming, thereby exerting pro-inflammatory or anti-inflammatory effects, which is closely associated with the risk of ischemic stroke. Their specific metabolic pathways involve glucose metabolism, lipid metabolism, and amino acid metabolism. This article reviews regulatory mechanisms of microglia metabolism after ischemic stroke and their role in ischemic stroke.
