Endothelial glycocalyx: a potential therapeutic target for cerebrovascular diseases
10.3760/cma.j.issn.1673-4165.2024.03.006
- VernacularTitle:内皮糖萼：脑血管病的潜在治疗靶点
- Author:
Yisong LI
1
;
Juan ZHU
;
Mingjia YU
;
Jiawei XU
;
Kaibin HUANG
;
Suyue PAN
Author Information
1. 南方医科大学南方医院神经内科，广州 510515
- Keywords:
Glycocalyx;
Endothelium, vascular;
Blood-brain barrier;
Cerebrovascular disorders;
Ischemic stroke;
Subarachnoid hemorrhage;
Cerebral small vessel diseases
- From:
International Journal of Cerebrovascular Diseases
2024;32(3):191-196
- CountryChina
- Language:Chinese
-
Abstract:
Blood brain barrier (BBB) injury is the main pathological manifestation of many neurological diseases. Glycocalyx is the gel layer covering the lumen side of vascular endothelial cells, which plays an important role in regulating BBB function. However, glycocalyx is very fragile and easily damaged in various neurological diseases, leading to BBB destruction. This article focuses on the potential role of glycocalyx in cerebrovascular disease, the possible mechanisms related to glycocalyx and BBB injury, and explores the potential therapeutic strategies for protecting and restoring endothelial glycocalyx.
