The predictive value of neutrophil percentage-to-albumin ratio on the outcome after intravenous thrombolysis in elderly patients with acute ischemic stroke
10.3760/cma.j.issn.1673-4165.2024.03.001
- VernacularTitle:中性粒细胞百分比与白蛋白比值对老年急性缺血性卒中患者静脉溶栓后转归的预测价值
- Author:
Xiaotao ZHANG
1
;
Mingfeng ZHAI
;
Wei WANG
Author Information
1. 阜阳市人民医院检验科 236000
- Keywords:
Ischemic stroke;
Thrombolytic therapy;
Neutrophils;
Serum albumin;
Treatment outcome;
Predictive value of tests
- From:
International Journal of Cerebrovascular Diseases
2024;32(3):161-166
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the predictive value of neutrophil percentage-to-albumin ratio (NPAR) on the outcome after intravenous thrombolysis (IVT) in elderly patients with acute ischemic stroke (AIS).Methods:Elderly patients with AIS who received IVT in Fuyang People's Hospital from October 2021 to September 2023 were retrospectively included. Clinical outcome were assessed by the modified Rankin Scale at 90 days after onset, with a score of >2 defined as poor outcome. Multivariate logistic regression analysis was used to determine the association between NPAR and poor clinical outcome after IVT in elderly AIS patients. Receiver operating characteristic (ROC) curves were used to evaluate the predictive value of NPAR for poor outcome. Results:A total of 148 patients were included, including 86 males (58.1%), aged (74.11±6.17) years. The median baseline National Institutes of Health Stroke Scale (NIHSS) score was 5 (interquartile range: 3-8), and the NPAR was 1.58±0.30. The neutrophil count, neutrophil percentage, NPAR, fasting blood glucose and baseline NIHSS score in the poor outcome group were significantly higher than those in the good outcome group (all P<0.05). Multivariate logistic regression analysis showed that higher baseline NPAR (odds ratio [ OR] 2.659, 95% confidence interval [ CI] 1.117-5.324; P<0.001), NIHSS score ( OR 1.191, 95% CI 1.083-1.309; P<0.001) and fasting blood glucose ( OR 1.224, 95% CI 1.013-1.479; P=0.037) were independent risk factors for poor outcome. ROC curve analysis showed that the area under the curve for NPAR to predict poor outcome was 0.712 (95% CI 0.613-0.812; P<0.001), the optimal cut-off value was 1.728, and the predictive sensitivity and specificity were 65.1% and 75.2%, respectively. Conclusion:Higher baseline NPAR may be a predictor of poor outcome after IVT in elderly AIS patients.
