Advances in molecular characteristics,detection methods,and clinical applications of serum HBV RNA
10.3969/j.issn.1673-4130.2024.22.023
- VernacularTitle:血清HBV RNA分子特征、检测方法及临床应用研究
- Author:
Xiaohua LIU
1
;
Yang YU
;
Guixiang WANG
;
Linyan ZHANG
;
Tao CHEN
;
Huacui HUANG
Author Information
1. 成都市新都区人民医院医学检验科,四川成都 610500
- Keywords:
hepatitis B virus;
hepatitis B virus RNA;
molecular characteristics;
detection methods;
clinical application
- From:
International Journal of Laboratory Medicine
2024;45(22):2805-2808,2816
- CountryChina
- Language:Chinese
-
Abstract:
Covalently closed circular DNA(cccDNA)in hepatocytes is the replication intermediate of hepa-titis B virus(HBV),which is closely related to HBV replication.Meanwhile,it is the transcriptional template of pregenomic RNA(pgRNA),and most of the HBV RNA in serum is derived from unreversed transcribed pgRNA.In recent years,many studies have demonstrated that HBV RNA has an important role in monitoring disease progression and predicting the prognosis of chronic HBV-infected patients,and is a potential biomarker of chronic viral hepatitis B.This article provides an overview of the molecular characterisation of HBV RNA,detection methods and research progress in clinical applications.
