Predictive value of serum Actinin-4 and NDRG4 for postoperative recurrence and metastasis in early stage lung cancer patients undergoing radical surgery
10.3969/j.issn.1673-4130.2024.22.011
- VernacularTitle:血清Actinin-4和NDRG4对早期肺癌患者根治术后复发转移的预测价值
- Author:
Xiaoqiang WANG
1
;
Yuman SUN
;
Xuan ZHENG
;
Xinxin ZHAO
;
Jingjing ZHENG
Author Information
1. 唐山职业技术学院附属医院胸外科,河北唐山 063000
- Keywords:
early lung cancer;
recurrence and metastasis;
Actinin-4;
N-myc downscream regulated gene 4
- From:
International Journal of Laboratory Medicine
2024;45(22):2743-2746
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of serum Actinin-4 and N-myc downscream regu-lated gene 4(NDRG4)for recurrence and metastasis in early stage lung cancer patients.Methods A total of 110 patients who underwent early lung cancer radical surgery in the hospital from January 2020 to January 2022 were collected as the study subjects.They were separated into a recurrence group of 62 patients and a non recurrence group of 48 patients based on whether they experienced recurrence or metastasis during a one-year follow-up.Enzyme-linked immunosorbnent assay(ELISA)method was applied to detect serum Actinin-4 and NDRG4 levels.Pearson and Spearman methods were used for correlation analysis.Logistic regression was applied to analyze the influencing factors of recurrence and metastasis in early stage lung cancer patients after radical surgery.Receiver operating characteristic(ROC)curve was applied to analyze the predictive value of serum Actinin-4 and NDRG4 levels for recurrence and metastasis in early stage lung cancer patients after radi-cal surgery.Results Compared with the non recurrence group,the serum Actinin-4 level in the recurrence group was obviously increased,while the NDRG4 level was obviously reduced,and there was a obvious differ-ence in TNM staging and lymph node metastasis between the two groups(P＜0.05).Pearson analysis showed that there was a negative correlation between serum Actinin-4 and NDRG4 levels in the recurrence group(r=-0.566,P＜0.05).Spearman analysis showed that Actinin-4 was positively correlated with lymph node me-tastasis and clinical staging(r=0.429,0.396,P＜0.05),while NDRG4 was negatively correlated with lymph node metastasis and clinical staging(r=-0.411,-0.431,P＜0.05).Logistic regression analysis showed that lymph node metastasis,clinical staging,Actinin-4,and NDRG4 levels could all be used as influencing fac-tors for postoperative recurrence and metastasis in early stage lung cancer patients after radical surgery(P＜0.05).ROC curve analysis showed that the area under the curve(AUC)of serum Actinin-4 and NDRG4 in predicting postoperative recurrence and metastasis in early stage lung cancer patients after radical surgery was 0.857 and 0.848,respectively,and the AUC of combined prediction was 0.950,which was better than those of the two single predictions(P＜0.05).Conclusion Serum Actinin-4 level increases and NDRG4 level decrea-ses in early stage lung cancer patients with postoperative recurrence and metastasis after radical surgery.The combined detection of the two could serve as an auxiliary indicator for predicting postoperative recurrence and metastasis in early stage lung cancer patients after radical surgery.
