Correlation of TG/HDL-C,TyG and derivatives with carotid atherosclerosis in patients with impaired glucose tolerance
10.3969/j.issn.1673-4130.2024.22.005
- VernacularTitle:糖耐量减低人群TG/HDL-C、TyG及衍生指标与颈动脉粥样硬化关系
- Author:
Cheng LIN
1
;
Zhijia TANG
;
Qian SHEN
Author Information
1. 安徽中医药大学附属铜陵中医医院检验科,安徽铜陵 244000
- Keywords:
triglyceride/high-density lipoprotein cholesterol;
triglyceride-glucose index;
impaired glu-cose tolerance;
carotid atherosclerosis
- From:
International Journal of Laboratory Medicine
2024;45(22):2710-2715
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of triglyceride/high-density lipoprotein cholesterol(TG/HDL-C),triglyceride-glucose index(TyG)and derivatives with carotid atherosclerosis(CAS)in pa-tients with impaired glucose tolerance(IGT).Methods Clinical data of totally 102 IGT patients admitted to Tongling Hospital of Traditional Chinese Medicine from March 2021 to March 2023 were retrospectively ana-lyzed.Patients were classified into CAS group and non-CAS group according to the presence or absence of CAS.Univariate and multivariate Logistic regression models were utilized to testify whether TG/HDL-C,TyG and derivatives were responsible for CAS in IGT patients,and receiver operating characteristic(ROC)curve was plotted,then Spearman correlation coefficient was calculated to verify the correlation of TG/HDL-C,TyG and their derivatives with carotid intima-media thickness(IMT).Results There were 57 patients with CAS and 45 patients without CAS,with an incidence of 55.88％.There were statistically significant differences in age,high density lipoprotein cholesterol(HDL-C),triglycerides(TG),body mass index(BMI),TG/HDL-C,waist hip ratio(WHR),IMT between the two groups(P＜0.05).The TyG and derivatives in the CAS group were higher than those in the non-CAS group,and the differences were statistically significant(P＜0.05).TG/HDL-C,TyG and derivatives were positively correlated with IMT(both P＜0.05).Age,TG/HDL-C,WHR,TyG and derivatives were the factors influencing the occurrence of CAS in IGT patients(P＜0.05).The cut-off values of TG/HDL-C TyG were 1.04 and 9.10,the area under the curve(AUC)of the combined prediction for the CAS in IGT patients was 0.920(95％CI:0.865-0.974),which was larger than that of sin-gle prediction[0.831(95％CI:0.749-0.913),0.737(95％CI:0.641-0.833)].Conclusion TG/HDL-C,TyG and derivatives in IGT patients are closely correlated with IMT,which have a certain value in predicting CAS.Besides,age,TG/HDL-C,TyG and derivatives,and WHR are the influencing factors for the occurrence of CAS in IGT patients.
