Clinical application of peripheral blood circular RNA in the diagnosis of gastrointestinal tumors
10.3969/j.issn.1673-4130.2024.21.022
- VernacularTitle:外周血环状RNA在消化道肿瘤诊断中的临床应用价值研究
- Author:
Zhuoting HAN
1
;
Xiaochong LIN
;
Tao ZENG
Author Information
1. 广东医科大学附属第二医院检验医学科,广东湛江 524003
- Keywords:
peripheral blood;
circular RNA;
gastrointestinal tumor;
diagnose;
application value
- From:
International Journal of Laboratory Medicine
2024;45(21):2675-2680
- CountryChina
- Language:Chinese
-
Abstract:
Circular RNA(circRNA)is a new type of non-coding RNA molecule with covalent closed-loop structure.CircRNA is involved in various processes of tumor development,such as tumor angiogenesis,epithe-lial-mesenchymal transformation(EMT),drug resistance,invasion,etc.CircRNA could enter the blood circu-lation in the form of exosomes and microvesicles,and is not easily degraded by nuclease,and could exist stably in the blood circulation.The progression of gastrointestinal tumors is closely related to the expression level of circRNA in peripheral blood,and peripheral blood circRNA may be a potential novel non-invasive diagnostic marker for gastrointestinal tumors.This article reviews the research progress of circRNA in the diagnosis of gastrointestinal tumors,focusing on the clinical application value of peripheral blood circRNA in the diagnosis of gastrointestinal tumors.
