Value of serum LTBP2,Ucn1,and CD90 levels in the diagnosis and severity assessment of endometriosis
10.3969/j.issn.1673-4130.2024.21.009
- VernacularTitle:血清LTBP2、Ucn1、CD90水平在子宫内膜异位症诊断及病情严重程度评估中的价值
- Author:
Jianfei ZHU
1
;
Yanyan XIE
Author Information
1. 扬州大学附属医院妇产科,江苏扬州 225009
- Keywords:
endometriosis;
latent transforming growth factor beta binding protein 2;
urocortin 1;
cluster of differentiation 90;
diagnosis;
severity
- From:
International Journal of Laboratory Medicine
2024;45(21):2605-2609
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of serum latent transforming growth factor beta binding protein 2(LTBP2),urocortin 1(Ucn1),and cluster of differentiation 90(CD90)levels in the diagnosis and severity assessment of endometriosis(EMT).Methods A total of 103 EMT patients who underwent diagno-sis and treatment in the hospital from January 2020 to December 2023 were selected as the experimental group.The experimental group was separated into a severe group and a mild group.In addition,82 healthy in-dividuals who underwent physical examinations in the hospital were selected as the control group.The correla-tion analysis of serum LTBP2,Ucn1,and CD90 levels was performed using Pearson.Multivariate Logistic re-gression was applied to analyze the influencing factors of EMT.Receiver operating characteristic(ROC)curve was applied to evaluate the diagnostic value of serum LTBP2,Ucn1,and CD90 for EMT.Results Compared with the control group,the serum levels of LTBP2,Ucn1,and CD90 in the experimental group showed an in-crease trend(P＜0.05).There was positive correlation between serum LTBP2,Ucn1,and CD90 in the experi-mental group(r=0.377,0.344,0.246,P＜0.001,＜0.001,=0.012).The serum levels of LTBP2,Ucn1,and CD90 were significantly higher in the mild group and the severe group than those in the control group(P＜0.05).The serum levels of LTBP2,Ucn1,and CD90 in the mild group were obviously lower than those in the severe group,and the differences were statistically significant(P＜0.05).The interleukin(IL)-4 level in the experimental group was lower than that in the control group,and the proportions of menstrual pain and pelvic surgery were higher than those in the control group,and the differences were statistically significant(P＜0.05).Serum levels of LTBP2,Ucn1,and CD90,menstrual pain,and a history of pelvic surgery were risk factors for EMT(P＜0.05),while IL-4 level was a protective factor for EMT(P＜0.05).The area under the curve of serum LTBP2,Ucn1,CD90,and their combination for EMT diagnosis was 0.788,0.801,0.810,and 0.916,with sensitivity of 63.11％,63.11％,62.14％,and 84.47％.The combination of the three(Z LTBP2-triple combination=4.054,P＜0.001,ZUcn1-triple combination=3.966,P＜0.0 01,Z CD90-triple combination=4.193,P＜0.001)had higher diagnostic value for EMT.Conclusion Patients with severe EMT have higher levels of serum LTBP2,Ucn1,and CD90.The com-bination of serum LTBP2,Ucn1,and CD90 has certain diagnostic value for EMT.
