Research progress of hypoxia inducible factor-1a in chronic kidney disease
10.3969/j.issn.1673-4130.2024.20.020
- VernacularTitle:缺氧诱导因子-1α在慢性肾脏病中的研究进展
- Author:
Xin LI
1
;
Xingmei LIU
;
Hua ZHANG
;
Fei MO
Author Information
1. 贵州医科大学医学检验学院,贵州贵阳 550025
- Keywords:
hypoxia inducible factor-1α;
chronic kidney disease;
inflammation;
fibrosis;
ferroptosis
- From:
International Journal of Laboratory Medicine
2024;45(20):2529-2533,2538
- CountryChina
- Language:Chinese
-
Abstract:
Chronic kidney disease(CKD)often begins subtly,with its prevalence steadily rising over time,some patients may already be in end-stage renal disease by the time they seek treatment,making it a signifi-cant global public health concern.Early and prompt diagnosis and treatment are crucial in slowing disease ad-vancement,enhancing patients'quality of life,and ultimately improving prognosis.Current studies have shown that hypoxia,directly or indirectly induced,is an important pathological mechanism in the occurrence and de-velopment of CKD,and hypoxia inducible factor-1α(HIF-1α)is one of the main nuclear transcription factors in the body's response to hypoxia.It plays an important role in the occurrence and development of kidney dis-eases in the process of energy metabolism,angiogenesis,apoptosis,tissue inflammation and fibrosis.There-fore,this article briefly reviews the research progress of HIF-1α in CKD,and provides more effective strategies for the prevention and treatment of CKD.
