Relationship between serum miR-892b and GROβ levels and clinicopathological features and prognosis in patients with gastric cancer
10.3969/j.issn.1673-4130.2024.20.015
- VernacularTitle:胃癌患者血清miR-892b、GROβ水平与临床病理特征、预后的关系
- Author:
Simin WEN
1
;
Ting LYU
;
Lei LEI
;
Lingling WANG
;
Liangyu SHI
Author Information
1. 陕西省核工业二一五医院消化内科,陕西咸阳 712000
- Keywords:
gastric cancer;
microRNA-892b;
growth-associated oncogene product β;
prognosis
- From:
International Journal of Laboratory Medicine
2024;45(20):2506-2510
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum levels of microRNA-892b(miR-892b)and growth-associat-ed oncogene product β(GROβ)in patients with gastric cancer and their clinical significance.Methods A total of 124 patients with gastric cancer admitted to the hospital from February 2019 to February 2022 were select-ed as the gastric cancer group,and 100 volunteers with normal gastroscopy were selected as the control group during the same period.Serum levels of miR-892b and GROβ were detected in the two groups,and the rela-tionship between serum levels of miR-892b and GROβ and clinicopathological characteristics of patients with gastric cancer was analyzed.Multivariate Cox regression analysis was used to explore the influencing factors of prognosis of patients with gastric cancer.Results The serum level of miR-892b in gastric cancer group was lower than that in control group,and the serum level of GROβ was higher than that in control group(P＜0.05).There were statistically significant differences in serum miR-892b and GROβ levels in gastric cancer pa-tients with different degrees of differentiation,maximum tumor diameter lymph node metastasisand TNM stage(P＜0.05).A total of 124 patients with gastric cancer were followed up for one year after discharge,91 patients survived,and the overall survival rate was 73.39％.The one year overall survival rate of gastric cancer patients was related to the degree of differentiation,maximum tumor diameter,lymph node metastasis and TNM stage(P＜0.05).The overall survival rate of gastric cancer patients with high expression of serum miR-892b and low expression of GROβ was higher than that of patients with low expression of serum miR-892b and high expression of GROβ(P＜0.05).Multivariate Cox regression analysis showed poor differentia-tion(HR=1.839,95％CI 1.048-3.227),lymph node metastasis(HR=1.791,95％CI 1.076-2.982),TNM stage Ⅲ-Ⅳ(HR=1.660,95％CI 1.015-2.715),low expression of serum miR-892b(HR=3.040,95％CI 1.592-5.805),high expression of serum GROβ(HR=2.277,95％CI 1.503-3.451)were risk fac-tors for the prognosis of gastric cancer patients(P＜0.05).Conclusion The serum level of miR-892b is de-creased and the level of GROβ is increased in patients with gastric cancer,which is closely related to the occur-rence and development of gastric cancer.The expression of miR-892b and GROβ is related to the clinicopatho-logical characteristics and prognosis of patients,and can be used as a biological indicator to evaluate the prog-nosis of patients with gastric cancer.
