Value of combined detection of CRP,PCT,IFN-γ,IL-6 and IFN-γ/IL-10 in early clinical diagnosis of HIV/TB co-infection
10.3969/j.issn.1673-4130.2024.20.012
- VernacularTitle:CRP、PCT、IFN-γ、IL-6及IFN-γ/IL-10的联合检测对HIV/TB双重感染的临床早期诊断价值
- Author:
Wenwan GAO
1
;
Feng ZHOU
;
Peibo LI
;
Xiao FU
;
Chengli WEI
;
Pengsen WANG
;
Ying HE
;
Tongxin LI
Author Information
1. 重庆市公共卫生医疗救治中心中心实验室,重庆 400036
- Keywords:
C-reactive protein;
procalcitonin;
cytokine;
human immunodeficiency virus;
tuberculosis
- From:
International Journal of Laboratory Medicine
2024;45(20):2491-2495
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expression differences of C-reactive protein(CRP),procalcitonin(PCT)and cytokines[interferon-γ(IFN-γ),tumor necrosis factor-α(TNF-α),interleukin(IL)-10,IL-6,IL-4,IL-2,IL-17 A,and IFN-γ/IL-10]in human immunodeficiency virus(HIV)infection,tuberculosis(TB)infec-tion and HIV/TB co-infection in order to provide evidence for early clinical diagnosis of HIV/TB co-infection.Methods Medical records and clinical information of 103 patients with HIV(HIV group),42 patients with TB(TB group)and 67 patients with HIV/TB co-infection(HIV/TB group)were collected from January 2021 to September 2022.CRP,PCT and cytokines were detected in all patients,and their expression differ-ences among the three groups were analyzed.Receiver operating characteristic(ROC)curves were drawn and screening ability was evaluated.Results Compared with HIV group and TB group,CRP,PCT,IFN-γ,IL-10,IL-6 levels and IFN-γ/IL-10 in HIV/TB group were increased,with statistical significance(P＜0.001).Bon-ferroni correction results showed that CRP,PCT,IFN-γ,IL-6 levels and IFN-γ/IL-10 were significantly differ-ent between HIV and HIV/TB groups(all P＜0.001).ROC curve analysis showed that the area under the curve of CRP,PCT,IFN-γ,IL-6 and IFN-γ/IL-10 combined detection was 0.826,which was higher than that of single detection.Conclusion CRP,PCT,IFN-γ,IL-6,IFN-γ/IL-10 combined detection can help the early screening of HIV infection and HIV/TB co-infection.
