Relationship between serum HMGB1 and CTRP3 levels and the degree of pain and lumbar function in patients with lumbar spinal stenosis
10.3969/j.issn.1673-4130.2024.20.007
- VernacularTitle:血清HMGB1、CTRP3水平与腰椎椎管狭窄症患者疼痛程度及腰椎功能的关系
- Author:
Wentao AN
1
;
Pin LYU
;
Ruifeng LI
;
Hao ZHOU
Author Information
1. 华北医疗健康集团峰峰总医院骨四科,河北邯郸 056000
- Keywords:
lumbar spinal stenosis;
high mobility group protein B1;
C1q/TNF-associated protein 3;
pain degree;
lumbar function
- From:
International Journal of Laboratory Medicine
2024;45(20):2467-2470,2475
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum high mobility group protein B1(HMGB1),C1q/TNF-associated protein 3(CTRP3)and pain degree and lumbar function.Methods A total of 145 patients with lumbar spinal stenosis treated in the hospital from September 2021 to August 2023 were retrospectively selected as the study objects,and were divided into single-segment group(89 cases)and multi-segment group(56 cases)according to the number of lumbar spinal stenosis segments.Serum levels of HMGB1 and CTRP3 were detected by enzyme-linked immunosorbent assay.The clinicopathological features such as pain degree,lumbar function and serum levels of HMGB1 and CTRP3 were compared between the two groups.The correlation of serum HMGB1 and CTRP3 levels with pain degree and lumbar function were ana-lyzed,and the factors influencing the number of segments of lumbar stenosis were analyzed by multivariate Logistic regression.The diagnostic value of serum HMGB1 and CTRP3 levels on lumbar function of patients was analyzed by receiver operating characteristic(ROC)curve.Results Visual analogue scale(VAS)score and serum HMGB1 level in multi-segment group were higher than those in single-segment group(P＜0.05),Japanese Orthopaedic Association(JOA)score and serum CTRP3 level were lower than those in single-seg-ment group(P＜0.05).Serum HMGB1 level was negatively correlated with CTRP3 and JOA score in pa-tients with lumbar spinal stenosis(r=-0.544,-0.616,P＜0.001),and positively correlated with VAS score(r=0.453,P＜0.001).The serum CTRP3 level was negatively correlated with VAS score(r=-0.550,P＜0.001),and positively correlated with JOA score(r=0.619,P＜0.001).JOA score was nega-tively correlated with VAS score(r=-0.485,P＜0.001).Multivariate Logistic regression analysis showed that JOA score and serum CTRP3 level were protective factors for multi-segmental stenosis(P＜0.05),VAS score and serum HMGB1 level were risk factors for multi-segmental stenosis(P＜0.05).The analysis of ROC curve showed that serum HMGB1 and CTRP3 levels could be used as diagnostic indexes of lumbar spinal function in patients with lumbar spinal stenosis,and the combined diagnosis effect was better(P＜0.05).Conclusion Serum levels of HMGB1 and CTRP3 are closely related to pain degree and lumbar function in pa-tients with lumbar spinal stenosis.The combination of the two indexes can be used for the clinical diagnosis of lumbar function in patients with lumbar spinal stenosis.
