Establishment and verification of reference intervals for blood cell ratios in apparently healthy people
10.3969/j.issn.1673-4130.2024.19.018
- VernacularTitle:表观健康人群血液细胞比值参考区间的建立与验证
- Author:
Jingzhu NAN
1
,
2
;
Xu ZHANG
;
Hui YUAN
;
Xuemei WEI
;
Shuai ZHANG
;
Chen WANG
;
Xiujuan LI
;
Honghao LU
;
Xiaoran SHEN
Author Information
1. 首都医科大学附属北京安贞医院检验科,北京 100029
2. 解放军总医院第一医学中心检验科,北京 100853
- Keywords:
neutrophil to lymphocyte ratio;
monocyte to lymphocyte ratio;
platelet to lymphocyte rati-o;
reference intervals
- From:
International Journal of Laboratory Medicine
2024;45(19):2396-2402,2407
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the reference intervals of neutrophil to lymphocyte ratio(NLR),mono-cyte to lymphocyte ratio(MLR)and platelet to lymphocyte ratio(PLR)in different genders and age groups in northern Chinese adults.Methods The data were analyzed according to the Clinical and Laboratory Stand-ards Institute C28-A3.Outliers were checked and judged according to the Dixon method.Subgroups were di-vided according to gender or age factors,and reference intervals were established for different subgroups.Ref-erence intervals were expressed as two-sided 95％percentiles.Results The reference intervals of NLR,MLR and PLR were 0.90-3.82,0.09-0.33 and 71.20-246.87,respectively.The results showed that NLR and PLR in men were lower than those in women(P＜0.001),while MLR in men was significantly higher than that in women(P＜0.001).Linear trend plots showed that NLR,MLR and PLR changed significantly in dif-ferent genders and age groups.In men,NLR and MLR increased with age,while PLR gradually increased and reached the peak before 50 years old,and gradually decreased after 50 years old.In women,NLR and MLR showed the lowest values at 50-＜60 years old,while PLR reached the peak at about 50 years old.The refer-ence intervals established by the model set were verified,and the percentages beyond the reference intervals were less than 10％in different genders and age groups.Conclusion The reference intervals of NLR,MLR and PLR in different genders and age groups of healthy adults in northern China are established in the study.
