Serum ADA and SERPINE1 levels and their clinical significance in patients with type 2 diabetes mellitus and acute cerebral infarction
10.3969/j.issn.1673-4130.2024.19.010
- VernacularTitle:2型糖尿病合并急性脑梗死患者血清ADA、SERPINE1水平及临床意义
- Author:
Jiangbo HUANG
1
;
Jian WANG
;
Ying SHAO
Author Information
1. 西安工会医院急诊科,陕西西安 710100
- Keywords:
type 2 diabetes mellitus;
acute cerebral infarction;
adenosine deaminase;
plasminogen ac-tivator inhibitor 1
- From:
International Journal of Laboratory Medicine
2024;45(19):2354-2359
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prognostic value of serum adenosine deaminase(ADA)and plas-minogen activator inhibitor 1(SERPINE1)levels in patients with type 2 diabetes mellitus(T2DM)complicat-ed with acute cerebral infarction(ACI).Methods A total of 195 patients with T2DM combined with ACI(ACI group)and 174 patients with T2DM alone(control group)admitted to Xi'an Labor Union Hospital from March 2019 to March 2023 were selected.The levels of serum ADA and SERPINE1 were compared be-tween ACI group and control group,and patients with different degrees of neurological defect and prognosis.The influencing factors of poor prognosis in T2DM patients with ACI were analyzed,and the value of each in-dex in predicting poor prognosis was evaluated.Results The levels of ADA and SERPINE1 in ACI group were significantly higher than those in control group(P＜0.05).With the aggravation of neurological deficit in T2DM patients with ACI,serum ADA and SERPINE1 levels increased(P＜0.05).The levels of serum ADA and SERPINE1 in the poor prognosis group were higher than those in the good prognosis group(P＜0.05).Severe neurological deficit and high levels of ADA,SERPINE1 and HbA1c were risk factors for poor prognosis in T2DM patients with ACI(P＜0.05).The area under the curve(AUC)of ADA combined with SERPINE1 for predicting the prognosis of T2DM patients with ACI was 0.896,which was higher than that of Ada and SERPINE1 alone(P＜0.05).Conclusion Elevated serum ADA and SERPINE1 levels are associated with severe neurological deficits and poor prognosis in T2DM patients with ACI.Combined detection of ADA and SERPINE1 can predict poor prognosis in T2DM patients with ACI.
