Diagnostic value of serum LMNA and LTB4 for adverse pregnancy outcomes in patients with hypertensive disorders of pregnancy
10.3969/j.issn.1673-4130.2024.19.007
- VernacularTitle:血清LMNA、LTB4对妊娠期高血压疾病患者妊娠不良结局的诊断价值
- Author:
Ni LI
1
;
Caimei WANG
;
Shuai KOU
Author Information
1. 西安交通大学第一附属医院榆林医院妇产科,陕西榆林 719000
- Keywords:
hypertensive disorders of pregnancy;
lamin A;
leukotriene B4;
adverse pregnancy outcomes
- From:
International Journal of Laboratory Medicine
2024;45(19):2340-2344
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of serum lamin A(LMNA)and leukotriene(LT)B4 for adverse pregnancy outcomes in patients with hypertensive disorders of pregnancy(HDP).Methods A total of 83 HDP patients admitted to the hospital from January 2021 to May 2023 were selected as the HDP group and 83 healthy pregnant women in the same period were selected as the control group.According to the pregnancy outcome,the HDP patients were divided into a poor outcome group(38 cases)and a good outcome group(45 cases).Serum LMNA and LTB4 levels were measured by enzyme-linked immunosorbent assay.Multivariate Logistic regression was used to analyze the influencing factors of adverse pregnancy outcomes in patients with HDP.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of serum LMNA and LTB4 levels for adverse pregnancy outcomes in patients with HDP.Results Compared with the control group,the serum LMNA level was decreased and the LTB4 level was increased in the HDP group(P＜0.05).Compared with the good outcome group,the serum LMNA level was significantly de-creased,and the LTB4 level was increased in the poor outcome group(P＜0.05).Preeclampsia,severe pre-eclampsia and elevated LTB4 level were independent risk factors for adverse pregnancy outcomes in patients with HDP,and elevated LMNA level was an independent protective factor(P＜0.05).The area under the curve of serum LMNA and LTB4 levels in the diagnosis of adverse pregnancy outcomes of HDP patients was 0.873,which was larger than 0.787 and 0.786 of serum LMNA and LTB4 levels alone(P＜0.05).Conclusion De-creased serum LMNA and increased LTB4 levels are associated with adverse pregnancy outcomes in patients with HDP.Combined detection of serum LMNA and LTB4 levels have a high diagnostic value for adverse pregnancy outcomes in patients with HDP.
